| Biography | |
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 Prof. Chunfu Zheng Fujian Medical University, China |
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| Title: Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by HSV-1 | |
| Abstract: Recognition of virus-derived nucleic acids by host pattern recognition receptors (PRRs) is crucial for early defense against viral infections. Recent studies revealed that PRRs also include several newly identified DNA sensors, most of which could activate the downstream adaptor stimulator of interferon genes and lead to the production of host antiviral factors. Herpes simplex virus type 1 (HSV-1) is extremely successful to establish an effective infection due to its capacity to counteract host innate antiviral responses. In the present review, I summarized the most recent findings on the molecular mechanisms utilized by HSV-1 to target different steps of the cellular DNA sensor-mediated antiviral signal pathway.
KEYWORDS | |
| Biography: Dr. Chunfu Zheng is currently a Professor of Fujian Medical University, China and also an adjunct professor with the University of Calgary, Canada. Dr. Zheng received his PhD on Infectious Diseases from Chongqing Medical University, China. He then worked at Wuhan Institute of Virology, Chinese Academy of Sciences as a Senior Scientist and Soochow University as a Professor. Dr. Zheng was a recipient of the One-Hundred Talents Program of Chinese Academy of Sciences. He has been engaged in researches on molecular virology and viral immunology for many years and achieved remarkable successes, which received peer recognition both at home and abroad. He serves as a committee member of the International Herpes viruses Workshop. He also serves as an Editorial board member of Journal of Virology and Journal of Medical Virology, an Associate Editor of Virology Journal, a committee member of Virology Association of Chinese Society for Microbiology. Dr. Zheng holds a patent and has published more than 70 papers in various journals and books, including 20 papers in Journal of Virology. Research interests: 1. Molecular mechanisms of immune evasion of HSV-1. 2. Molecular mechanisms of HSV-1 infection and its interaction with the host. 3. Mechanisms of pathogenesis of HSV-1 infection. 4. Molecular mechanisms of HSV-1 latent infection. | |
