Biography
Prof. Ai-Yun Peng
Prof. Ai-Yun Peng
Sun Yat-sen University, China
Title: Tandem Reactions to construct phosphonamidates
Abstract: 
Phosphonamidates are important transition state analogues of carboxamides and have broad potential applications in the field of medicine and materials. However, the existing synthetic methods have apparent shortcomings, such as long steps, low yields, and harsh reaction conditions, which largely limit the synthesis and applications of them. In order to seek simple and efficient synthetic methods to phosphonamidates, we made a lot of attempts in recent years and finally developed a tandem reaction to prepare various phosphonamidates. The reaction started from the cheap and easily available halohydrocarbons, phosphites, iodine and amines, which provided a mild, general, easy to operate, high efficient, and atom-economical way to phosphonamidates.
Biography: 
Dr. Peng is now an associate professor of Organic Chemistry at the School of Chemistry, Sun Yat-sen University. She got her PhD from Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences (CAS) in 2004. After graduation, she has been working at sun Yat-sen University. During this time, she has ever gone to Ohio state university as a visiting scholar for one year (from 2011.4 to 2012.4). Her major research interests include: 1) development of new synthetic methodologies for useful organic molecules, especially the bioactive phosphorus compounds; 2) synthesis and biological evaluation of organic compounds with potential biological activities, including enzyme inhibition, anticancer and antibacterial; 3) optimize the production process of some pharmaceutical intermediates. Through these years of research, she has developed a series of new synthetic methodologies, synthesized various phosphonates and phosphoamidates with potential bioactivities and examined their enzyme inhibitory activities. Some of the research results were published in top-tier journals including J. Am. Chem. Soc., Org. Lett., J. Org. Chem., Org. Biomol. Chem.. Thus far, she has published nearly 30 papers and three authorized patents.