| Biography | |
|---|---|
 Prof. Haiyun Xu Shantou University Medical College, China |
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| Title: Evaluation of neuron-glia integrity by in vivo proton magnetic resonance spectroscopy: Implications for psychiatric disorders | |
| Abstract: Proton magnetic resonance spectroscopy (1H-MRS) has been widely applied in human studies. There is now a large literature describing findings of brain MRS studies with mental disorder patients including schizophrenia, bipolar disorder, major depressive disorder, and anxiety disorders. However, the findings are mixed and cannot be reconciled by any of the existing interpretations. Here we proposed the new theory of neuron-glia integrity to explain the findings of brain 1H-MRS studies. It proposed the neurochemical correlates of neuron-astrocyte integrity and axon-myelin integrity on the basis of update of neurobiological knowledge about neuron-glia communication and of experimental MRS evidence for impairments in neuron-glia integrity from the authors and the other investigators. Following the neuron-glia integrity theories, this review collected evidence showing that glutamate/glutamine change is a good marker for impaired neuron-astrocyte integrity and that changes in N-acetyl-aspartate and lipid precursors reflect impaired myelination. Moreover, this new theory enables us to explain the differences between MRS findings in neuropsychiatric and neurodegenerative disorders. | |
| Biography: EDUCATION 09/1998 - 02/2000 M.Sc. (Computer Science, Cardinal Stritch University, USA) 09/1993 - 07/1996 Ph.D. (Department of Anatomy, Peking Union Medical College, China) 09/1987 - 07/1990 M. M. (Department of Anatomy, Hubei Medical University, China) 09/1979 – 08/1984 B. M. (Clinical Medicine, Hubei Medical College, China) ACADEMIC APPOINTMENTS 09/2011 – Professor (Department of Anatomy and Mental Health Center, Shantou University Medical College) 09/2006 - 06/2011 Assistant Professor (Department of Anatomy, School of Medicine, Southern Illinois University Carbondale) 01/2003 - 08/2006 Research Associate (Department of Psychiatry, School of Medicine, University of Saskatchewan) 03/2000 - 12/2002 Post-doctoral Fellow (Department of psychiatry, School of Medicine, University of Saskatchewan) 09/1997 - 02/2000 Post-doctoral Fellow (Department of Biophysics, Medical College of Wisconsin) 09/1996 - 08/1997 Post-doctoral Fellow (Department of Anatomy & Neuroscience, Medical College of Wisconsin) 07/1990 - 08/1993 Lecturer (Department of Anatomy, Hubei Medical University) 08/1984 - 08/1987 Teaching Assistant (Department of Anatomy, Hubei Medical College) | |
