| Biography | |
|---|---|
 Prof. Valeria Sandrim Universidade do Estado de São Paulo, Brazil |
|
| Title: Biomarkers in preeclampsia: how can they may help to understand the syndrome | |
| Abstract:
BACKGROUND: Preeclampsia result in maternal and fetal complications and some studies have reported the role of MMPs and TIMPs in its pathophysiology. Therefore, the aim of this study was measure plasma TIMP-4 levels and correlate with expression of Let-7a-5p (3´UTR post-transcriptionally regulation) in preeclampsia and healthy pregnancy. METHODS: TIMP-4 was measured by ELISA and miR-Let7a-5p expression by qPCR in preeclampsia (n=13) and their respective healthy pregnant controls (n=12). RESULTS: Elevated plasma TIMP-4 levels in preeclampsia compared to healthy pregnant was found (1450 ± 411 vs. 775 ± 210 pg/mL, respectively; P<0.0001); and a negative correlation was found (r=-0.39, P=0.06, including both healthy and preeclampsia). CONCLUSIONS: TIMP-4 may be post-transcriptally regulated by Let-7a-5p. This may help to the understanding of physiopathology of disease. Keywords: preeclampsia, TIMP-4, TIMPs, MMPs, Let-7a-5p, microRNA, hypertension
| |
| Biography:
Biologist, master in biotechnology and PhD in pharmacology. Post-doctorate at Ribeirão Preto Medical School, with traineeship at Beth Israel Deaconess Medical Center-Harvard Medical School. She was awarded the Loreal / ABC / UNESCO Prize "For Women in Science" and the Prize promoted by Sanofi: Medical Services. He has published more than 100 articles in international journals. She develops research related to the study of preeclampsia, including biomarkers, prevention methods and therapies.
| |
