Dr. Jingan Li
Dr. Jingan Li
Zhengzhou University, China
Title: Conjugating functional molecules on cardiovascular biomaterials to direct the cells fate
Cardiovascular disease is generally accepted as the leading cause of morbidity and mortality worldwide, and lots of people suffer from atherosclerosis and thrombosis every year. To treat these disorders and prolong the patients’ life, the cardiovascular stents have been developed and applied clinically. Nevertheless, thrombosis and hyperplasia at the site of implanting cardiovascular stents are recognized as long-term problems in the practice of interventional cardiology. Although the drug-eluting stents make excellent contribution to treat early thrombosis and inflammation, the loading drugs also delay vascular healing and re-endothelialization, leading to high risk of late thrombosis and hyperplasia. Recent researches show that stent surface modification with functional molecules can significantly improve surface re-endothelialization and reduce the late thrombosis/hyperplasia, and this process is closely related to the crucial parameters of the conjugated molecules, including the molecular classification, size, distributed density and conformation. Therefore, reasonably conjugating functional molecules on the surface is of great importance for improving the biocompatibility of the cardiovascular stents. Here, we introduced several novel strategies on surface modification of cardiovascular biomaterials in our research group and discuss the prospects for extending use of the surface construction of functional molecules in designing the next generation of vascular stents. This work was supported by the Joint Fund for Fostering Talents of National Natural Science Foundation of China and Henan province (U1504310), China Postdoctoral Science Foundation (2015M582206), and Young Teachers Foundation of Zhengzhou University (No. 32210475)
Dr. Jingan Li has completed his PhD and postdoctoral studies from Southwest Jiaotong University, China. Now he is a associate professor of Zhengzhou University. He has published more than 30 papers in reputed journals and has been serving as an editorial board member and out standing reviewer of repute journals. He has been also invited to make invited talk, keynote speak and plenary lecture in major academic conferences, or to hold the session chair/co-chair in these conferences. He obtained the China-Krea Young Scientist Award at 2015 Chinese Biomaterials Congress, and Outstanding Reviewer Award of Materials & Engineering C in 2015. He was also awarded the IAAM Scientist Medal for his contribution to the advanced materials field. His current research is particularly focused on surface modification of cardiovascular biomaterials and degradable biomaterials.